Reactivation, interference, and reconsolidation: are recent and remote memories likewise susceptible?

Behavioral Neuroscience Reactivation, Interference, and Reconsolidation: Are Recent and Remote Memories Likewise Susceptible?

Propranolol–induced Impairment of Contextual Fear Memory Reconsolidation in Rats: A Similar Effect on Weak and Strong Recent and Remote Memories

Introduction: Previous studies have demonstrated that the &beta-adrenergic receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. There are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. In this study, we investigated the ability of the age and the strength o...

Sleep’s role in the reconsolidation of declarative memories

Sleep is known to support the consolidation of newly encoded and initially labile memories. Once consolidated, remote memories can return to a labile state upon reactivation and need to become reconsolidated in order to persist. Here we asked whether sleep also benefits the reconsolidation of remote memories after their reactivation and how reconsolidation during sleep compares to sleep-depende...

Activity in prelimbic cortex subserves fear memory reconsolidation over time.

The prelimbic cortex has been implicated in the consolidation of previously learned fear. Herein, we report that temporarily inactivating this medial prefrontal cortex subregion with the GABAA agonist muscimol (4.0 nmol in 0.2 μL per hemisphere) was able to equally disrupt 1-, 7-, and 21-d-old contextual fear memories after their brief retrieval in rats. In all cases, this effect was prevented ...

Changing memories after reactivation: a one-time opportunity?

After reactivation, apparently stable memories can become sensitive to modifications again, requiring another phase of stabilization, called reconsolidation. Recent evidence shows that repeated reactivations strengthen memories and that stronger memories are more resistant to alterations during reconsolidation. Therefore, we asked whether multiple reactivations make memories less vulnerable to ...